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However, clinical evidence for this specific combination remains limited, and such decisions should involve provider guidance and individual metabolic assessment

In addition, in cultured human tubular cells, cisplatin reduced SIRT3, resulting in mitochondrial fragmentation, while restoration of SIRT3 with ALC (200 or 500 mg/kg b.w., i.p .) improved cisplatin-induced mitochondrial dysfunction [102]

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Both approaches sidestep the pH clash that can happen when a peptide sits directly on top of a retinoid, and both let each active work in its own window